tension-based theory of c rphoge lesis and compact wiring in the central nervous system

Many structural features of the mammalian central nervous system can be explained by a morphogenetlc mechanism that involves mechanical tension along axonsdendrites and glial processes. In the cerebral cortex, for exampletension along axons in the white matter can explain how and why the cortex folds In a characteristic species-specific pattern. Iii the cerebellum, tension along parallel fibres can explain why the cortex is highly elongated but folded like an accordion. By keeping the aggregate length of axonal and dendritic wiring low, tension should contribute to the compactness of neural circuitry throughout the adult brain.